RESUMO
Presentamos una mujer embarazada de 37 semanas que consultó por la presencia de una erupción papulovesicular en el tronco de dos semanas de evolución. El examen histopatológico resultó compatible con enfermedad de Grover. Se trata de un caso atípico de una patología relativamente frecuente, en el que se discutimos la posible implicación del embarazo en la patogenia de la dermatosis acantolítica transitoria (AU)
A 37-year-old pregnant woman with a two week s papulovesicular eruption is reported. The histopathological examination showed a Grover s disease. This is an atypical case of a relatively common condition. Herein, we discuss the possible involvement of pregnancy in the pathogenesis of transientacantolitic dermatosis (AU)
Assuntos
Humanos , Feminino , Gravidez , Adulto , Acantólise/diagnóstico , Dermatopatias Vesiculobolhosas/diagnóstico , Complicações na Gravidez , Diagnóstico DiferencialRESUMO
El síndrome del glucagonoma es un cuadro paraneoplásico poco frecuente. Se caracteriza por la presencia de eritema necrolítico migratorio, diabetes mellitus, pérdida de peso, anemia, estomatitis, diarrea, alteraciones neuropsiquiátricas y fenómenos tromboembólicos, asociados a una tumoración pancreática de células alfa. El diagnóstico precoz es clave para poder realizar un tratamiento curativo mediante la extirpación del tumor. Presentamos el caso de una mujer de 70 años con síndrome del glucagonoma diagnosticado a partir de lesiones cutáneas en forma de eritema necrolítico migratorio (AU)
Glucagonoma syndrome is a rare paraneoplasic phenomenon. It is characterized by the existente of necrolytic migratory erythema, diabetes mellitus, weight loss, anemia, stomatitis, diarrhea, neuropsychiatric manifestations and thromboembolic events, associated to an alpha-cell tumor of the pancreas. Early detection provides the cure of the neoplasm by surgical removal. We present a 70-year-old woman with necrolytic migratory erythema as the presenting manifestation of glucagonoma syndrome (AU)
Assuntos
Humanos , Feminino , Idoso , Glucagonoma/diagnóstico , Eritema Migratório Necrolítico/diagnóstico , Neoplasias Pancreáticas/diagnóstico , Octreotida/uso terapêutico , Síndromes Paraneoplásicas/complicaçõesAssuntos
Humanos , Masculino , Idoso de 80 Anos ou mais , Úlcera Cutânea/complicações , Úlcera Cutânea/diagnóstico , Síndrome do Túnel Carpal/complicações , Síndrome do Túnel Carpal , Diagnóstico Precoce , Úlcera Cutânea/fisiopatologia , Úlcera Cutânea , Acro-Osteólise/complicações , Diagnóstico DiferencialAssuntos
Síndrome do Túnel Carpal/complicações , Dedos/patologia , Úlcera Cutânea/etiologia , Idoso de 80 Anos ou mais , Sedimentação Sanguínea , Reabsorção Óssea/complicações , Reabsorção Óssea/diagnóstico por imagem , Síndrome do Túnel Carpal/fisiopatologia , Doenças do Colágeno/diagnóstico , Diagnóstico Diferencial , Traumatismos dos Dedos/diagnóstico , Traumatismos dos Dedos/etiologia , Falanges dos Dedos da Mão/diagnóstico por imagem , Falanges dos Dedos da Mão/patologia , Dedos/inervação , Humanos , Hipestesia/etiologia , Hipestesia/fisiopatologia , Masculino , Nervo Mediano/fisiopatologia , Exame Físico , Radiografia , Úlcera Cutânea/patologiaRESUMO
Eosinophilic pustular folliculitis (EPF) is a rare, chronic disease of unknown cause, characterized by itchy papules or pustules and an infiltration of eosinophiles in the biopsy. EPF occurs rarely outside Japan and very few cases have been described in non-Japanese race people. The causes of the disease and its definitive treatment have not yet been established. In our patient, the presence of subcorneal pustules in the biopsies initially favored a diagnosis of pustulosis and several biopsies were necessary before a diagnosis of EPF was reached. A new case of EPF recently presented at our clinic and we have carried out an extensive revision of the disease.
Assuntos
Eosinofilia/patologia , Foliculite/patologia , Dermatopatias Vesiculobolhosas/patologia , Adulto , Feminino , HumanosRESUMO
La foliculitis pustulosa eosinofílica (FPE) es una enfermedad crónica, rara y de causa desconocida, que cursa con pápulas y/o pústulas pruriginosas y un infiltrado de eosinófilos en la biopsia. La FPE suele ocurrir con poca frecuencia fuera de Japón y son escasos los casos descritos en pacientes de raza no japonesa. Los factores causales de la enfermedad y su tratamiento definitivo no están establecidos todavía. En nuestra paciente, inicialmente, la presencia de pústulas subcorneales en las biopsias orientaba hacia un diagnóstico de dermatosis pustular; y fueron necesarias repetidas biopsias para obtener el diagnóstico de FPE. Presentamos un nuevo caso de FPE recientemente visto en nuestra consulta y hemos realizado una revisión extensa de la enfermedad
Eosinophilic pustular folliculitis (EPF) is a rare, chronic disease of unknown cause, characterized by itchy papules or pustules and an infiltration of eosinophiles in the biopsy. EPF occurs rarely outside Japan and very few cases have been described in non-Japanese race people. The causes of the disease and its definitive treatment have not yet been established. In our patient, the presence of subcorneal pustules in the biopsies initially favored a diagnosis of pustulosis and several biopsies were necessary before a diagnosis of EPF was reached. A new case of EPF recently presented at our clinic and we have carried out an extensive revision of the disease
Assuntos
Feminino , Adulto , Humanos , Foliculite/patologia , Eosinofilia/patologia , Técnicas Histológicas/métodosRESUMO
The purpose of this work was to study if the variations in the nuclear DNA content and the expression of EGFr and HER2/neu transmembrane oncoproteins were related and if this influences the rate of cell proliferation modifying, in each case, the potential aggressivity of the neoplasia. Thirty-four ductal breast carcinoma tissue samples of tumors of up to 2 cm in diameter were analyzed by flow cytometry. HER2/neu and EGFr were measured by immunohistochemical methods. Twenty cases were diploid (DNA index of 1) and 14 cases were aneuploid (DNA index other than 1). The expression of EGFr and HER2/neu was significantly higher in aneuploid tumors compared with diploid tumors. The cell proliferation rate was significantly higher in tumors with an aneuploid pattern. The expression of EGFr was associated with a higher rate of cell proliferation. The higher expression of EGFr and HER 2/neu oncoproteins in aneuploid tumors suggests that the increased proliferative activity of aneuploid carcinomas is influenced by the activity of such oncoproteins, which favors a more aggressive biological behavior.